Table 2.
The univariate and multivariate cox analysis of fifteen indicators in patients with lung cancer
| Model0 | Model1 | Model2 | |||||
|---|---|---|---|---|---|---|---|
| Cases/controls | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| NLR | |||||||
| Per SD (increased) | 1.17 (1.12,1.22) | <0.001 | 1.09 (1.03,1.15) | 0.002 | 1.05 (0.99,1.11) | 0.102 | |
| <3.36 | 527/634 | Reference | Reference | Reference | |||
| ≥3.36 | 399/212 | 1.85 (1.62,2.10) | <0.001 | 1.42 (1.24,1.62) | <0.001 | 1.29 (1.13,1.48) | <0.001 |
| PLR | |||||||
| Per SD (increased) | 1.10 (1.04,1.17) | 0.001 | 1.04 (0.97,1.11) | 0.253 | 0.99 (0.93,1.06) | 0.786 | |
| <207.00 | 644/665 | Reference | Reference | Reference | |||
| ≥207.00 | 282/181 | 1.40 (1.22,1.62) | <0.001 | 1.17 (1.02,1.35) | 0.028 | 1.06 (0.92,1.23) | 0.403 |
| GLR | |||||||
| Per SD (increased) | 1.15 (1.09,1.21) | <0.001 | 1.09 (1.04,1.16) | 0.001 | 1.06 (1.00,1.12) | 0.047 | |
| <5.27 | 668/710 | Reference | Reference | Reference | |||
| ≥5.27 | 258/136 | 1.56 (1.35,1.80) | <0.001 | 1.36 (1.17,1.57) | <0.001 | 1.26 (1.08,1.47) | 0.003 |
| ALI | |||||||
| Per SD (increased) | 0.79 (0.71,0.87) | <0.001 | 0.93 (0.85,1.02) | 0.124 | 0.97 (0.89,1.06) | 0.524 | |
| ≥34.19 | 391/515 | Reference | Reference | Reference | |||
| <34.19 | 535/331 | 1.89 (1.66,2.16) | <0.001 | 1.49 (1.30,1.7) | <0.001 | 1.30 (1.13,1.49) | <0.001 |
| SII | |||||||
| Per SD (increased) | 1.18 (1.12,1.25) | <0.001 | 1.09 (1.02,1.16) | 0.007 | 1.04 (0.98,1.11) | 0.183 | |
| <705.03 | 461/546 | Reference | Reference | Reference | |||
| ≥705.03 | 465/300 | 1.65 (1.45,1.87) | <0.001 | 1.29 (1.13,1.48) | <0.001 | 1.19 (1.04,1.37) | 0.010 |
| CAR | |||||||
| Per SD (increased) | 1.16 (1.09,1.24) | <0.001 | 1.08 (1.01,1.16) | 0.023 | 1.04 (0.97,1.12) | 0.269 | |
| <0.18 | 439/527 | Reference | Reference | Reference | |||
| ≥0.18 | 487/319 | 1.81 (1.59,2.06) | <0.001 | 1.45 (1.27,1.65) | <0.001 | 1.35 (1.18,1.54) | <0.001 |
| GNRI | |||||||
| Per SD (increased) | 0.78 (0.73,0.82) | <0.001 | 0.84 (0.78,0.90) | <0.001 | 0.87 (0.81,0.93) | <0.001 | |
| ≥207.0 | 537/589 | Reference | Reference | Reference | |||
| <207.0 | 389/257 | 1.70 (1.49,1.94) | <0.001 | 1.48 (1.28,1.71) | <0.001 | 1.36 (1.17,1.58) | <0.001 |
| mGNRI | |||||||
| Per SD (increased) | 0.78 (0.71,0.85) | <0.001 | 0.88 (0.81,0.95) | 0.002 | 0.91 (0.84,0.99) | 0.028 | |
| ≥96.05 | 353/437 | Reference | Reference | Reference | |||
| <96.05 | 573/409 | 1.78 (1.55,2.03) | <0.001 | 1.41 (1.22,1.63) | <0.001 | 1.29 (1.12,1.50) | <0.001 |
| AGR | |||||||
| Per SD (increased) | 0.81 (0.76,0.87) | <0.001 | 0.86 (0.80,0.92) | <0.001 | 0.88 (0.82,0.94) | <0.001 | |
| ≥1.24 | 553/584 | Reference | Reference | Reference | |||
| <1.24 | 373/262 | 1.58 (1.39,1.81) | <0.001 | 1.39 (1.21,1.59) | <0.001 | 1.31 (1.14,1.5) | <0.001 |
| PNI | |||||||
| Per SD (increased) | 0.79 (0.74,0.84) | <0.001 | 0.87 (0.81,0.93) | <0.001 | 0.91 (0.85,0.97) | 0.003 | |
| ≥48.60 | 317/408 | Reference | Reference | Reference | |||
| <48.60 | 609/438 | 1.62 (1.42,1.86) | <0.001 | 1.34 (1.17,1.54) | <0.001 | 1.24 (1.08,1.43) | 0.002 |
| NRI | |||||||
| Per SD (increased) | 0.78 (0.73,0.83) | <0.001 | 0.84 (0.78,0.90) | <0.001 | 0.87 (0.81,0.94) | <0.001 | |
| ≥97.17 | 536/589 | Reference | Reference | Reference | |||
| <97.17 | 390/257 | 1.71 (1.5,1.95) | <0.001 | 1.48 (1.28,1.72) | <0.001 | 1.37 (1.18,1.59) | <0.001 |
| LCR | |||||||
| Per SD (increased) | 0.73 (0.64,0.83) | <0.001 | 0.81 (0.72,0.92) | 0.001 | 0.83 (0.74,0.94) | 0.002 | |
| ≥2728.94 | 396/483 | Reference | Reference | Reference | |||
| <2728.94 | 530/363 | 1.77 (1.55,2.02) | <0.001 | 1.41 (1.23,1.61) | <0.001 | 1.28 (1.12,1.47) | <0.001 |
| CRP | |||||||
| Per SD (increased) | 1.18 (1.11,1.26) | <0.001 | 1.10 (1.03,1.18) | 0.006 | 1.05 (0.98,1.13) | 0.146 | |
| <9.02 | 495/567 | Reference | Reference | Reference | |||
| ≥9.02 | 431/279 | 1.76 (1.54,2.00) | <0.001 | 1.38 (1.21,1.58) | <0.001 | 1.27 (1.11,1.46) | <0.001 |
| CONUT | |||||||
| <2 | 388/464 | Reference | Reference | Reference | |||
| ≥2 | 538/382 | 1.49 (1.3,1.69) | <0.001 | 1.27 (1.11,1.46) | <0.001 | 1.20 (1.05,1.38) | 0.007 |
| mGPS | 0.56 (0.49,0.64) | <0.001 | 0.71 (0.62,0.81) | <0.001 | 0.77 (0.67,0.89) | <0.001 | |
| 0 | 518/581 | Reference | Reference | Reference | |||
| 1 | 271/182 | 1.66 (1.43,1.93) | <0.001 | 1.32 (1.13,1.53) | <0.001 | 1.23 (1.05,1.43) | 0.008 |
| 2 | 137/83 | 1.92 (1.59,2.32) | <0.001 | 1.45 (1.19,1.76) | <0.001 | 1.28 (1.04,1.56) | 0.019 |
| P for trend | 1.44 (1.32,1.57) | <0.001 | 1.23 (1.12,1.34) | <0.001 | 1.15 (1.05,1.26) | 0.003 | |
| LCS | |||||||
| 0 | 168/190 | Reference | Reference | Reference | |||
| 1 | 631/578 | 1.47 (1.24,1.74) | <0.001 | 1.2 (1.01,1.43) | 0.037 | 1.15 (0.96,1.37) | 0.121 |
| 2 | 127/78 | 1.96 (1.55,2.47) | <0.001 | 1.44 (1.14,1.81) | 0.002 | 1.23 (0.97,1.56) | 0.092 |
| P for trend | 1.40 (1.25,1.57) | <0.001 | 1.20 (1.07,1.35) | 0.002 | 1.11 (0.99,1.25) | 0.076 | |
Model0, unadjusted model; Model1, adjusted by age, sex, tumour stage, and BMI (except for ALI); Model2, adjusted by age, sex tumour stage, BMI (except for ALI), KPS, PG‐SGA, surgery, radiotherapy, chemotherapy, smoking, and alcohol drinking.
95% CI, 95% confidence interval; AGR, albumin‐to‐globulin ratio; ALI, advanced lung cancer inflammation index; CONUT score, controlling nutritional status score; CRP, C‐reactive protein; GLR, glucose‐to‐lymphocyte ratio; GNRI, geriatric nutritional risk index; HR, hazard ratio; LCR, lymphocyte‐to‐C‐reactive protein ratio; LCS, lymphocyte‐to‐C‐reactive protein ratio score; mGNRI, modified geriatric nutritional risk index; mGPS, modified Glasgow prognostic score; NLR, neutrophil‐to‐lymphocyte ratio; NRI, nutritional risk index; PLR, platelet‐to‐lymphocyte ratio; PNI, prognostic nutritional index; SD, standard deviation; SII, neutrophil immune‐inflammation index; CAR, C‐reactive protein‐to‐albumin ratio.