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. 2022 Jul 21;13(5):2456–2472. doi: 10.1002/jcsm.13045

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© 2022 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Common pathways and metabolites in the plasma and urine of main IIM subtypes. (A) KEGG pathway analysis of the dysregulated pathways in both the plasma and urine of dermatomyositis (DM), anti‐synthetase syndrome (ASS), and immune‐mediated necrotizing myopathy (IMNM) patients compared with normal control (NC) samples based on important metabolites (VIP > 1). (B) The important metabolites altered in both plasma and urine of DM, ASS, and IMNM patients, respectively (VIP > 1, FC > 1.2 or <0.83).