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. 2022 Sep 20;13:960570. doi: 10.3389/fimmu.2022.960570

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Copyright © 2022 Song, Wei, Huo, Liu and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The correlation between VCAN expression and the tumor microenvironment. (A) The correlation between VCAN expression with the infiltration of immune cells and stroma cells in tumor microenvironment (TCGA cohort). (B) The correlation between VCAN expression with the infiltration of CAFs in human pan-cancer (Pan-cancer Atlas, TCGA). (C) The correlation between VCAN expression with the infiltration of CAFs in patients with GC (TCGA cohort). (D) The correlation between VCAN expression with the expression of CAFs markers in patients with GC (TCGA cohort). (E) Kaplan–Meier curves of OS of low and high group stratified by the CAFs infiltration in patients with GC (TCGA cohort). *p < 0.05, **p < 0.01, and ***p < 0.001. GC: gastric cancer; CAFs: cancer associated fibroblasts.