Table 2.
List of genes differentially expressed in both right and left colon organoids following calcium supplementation.
| Right colon organoids (n = 21) | Left colon organoids (n = 15) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Ensembl | HGNC | log2Fold Change | lfcSEa | Statb | P | FDR | log2Fold Change | lfcSEa | Statb | P | FDR |
| ENSG00000134240 | HMGCS2 | 0.519 | 0.074 | 7.049 | 1.80E−12 | 8.69E−09 | 0.409 | 0.071 | 5.758 | 8.52E−09 | 2.63E−05 |
| ENSG00000196154 | S100A4 | 0.630 | 0.080 | 7.887 | 3.10E−15 | 4.49E−11 | 0.472 | 0.098 | 4.796 | 1.62E−06 | 1.74E−03 |
| ENSG00000131016 | AKAP12 | 0.419 | 0.088 | 4.782 | 1.73E−06 | 5.98E−04 | 0.446 | 0.073 | 6.106 | 1.02E−09 | 4.19E−06 |
| ENSG00000110080 | ST3GAL4 | 0.404 | 0.078 | 5.209 | 1.90E−07 | 1.86E−04 | 0.207 | 0.049 | 4.257 | 2.07E−05 | 9.97E−03 |
| ENSG00000069424 | KCNAB2 | 0.624 | 0.135 | 4.638 | 3.53E−06 | 1.06E−03 | 0.483 | 0.101 | 4.796 | 1.62E−06 | 1.74E−03 |
| ENSG00000144136 | SLC20A1 | 0.235 | 0.046 | 5.087 | 3.64E−07 | 2.41E−04 | 0.165 | 0.039 | 4.254 | 2.10E−05 | 9.97E−03 |
| ENSG00000134569 | LRP4 | 0.547 | 0.106 | 5.141 | 2.74E−07 | 2.17E−04 | 0.330 | 0.080 | 4.119 | 3.80E-05 | 0.016 |
| ENSG00000121898 | CPXM2 | 0.604 | 0.127 | 4.736 | 2.18E−06 | 7.19E−04 | 0.677 | 0.153 | 4.430 | 9.42E−06 | 5.28E−03 |
| ENSG00000167767 | KRT80 | 0.253 | 0.058 | 4.326 | 1.52E−05 | 3.10E−03 | 0.190 | 0.040 | 4.787 | 1.69E−06 | 1.74E−03 |
| ENSG00000180861 | LINC01559 | 0.426 | 0.107 | 3.999 | 6.36E−05 | 8.53E−03 | 0.248 | 0.050 | 4.957 | 7.15E−07 | 1.10E−03 |
| ENSG00000204983 | PRSS1 | −0.665 | 0.191 | −3.476 | 5.09E−04 | 0.035 | −0.692 | 0.078 | −8.916 | 4.83E−19 | 5.96E−15 |
| ENSG00000214049 | UCA1 | 0.331 | 0.067 | 4.924 | 8.49E−07 | 3.74E−04 | 0.230 | 0.057 | 4.025 | 5.70E−05 | 0.021 |
| ENSG00000183018 | SPNS2 | 0.204 | 0.045 | 4.566 | 4.97E−06 | 1.38E−03 | 0.199 | 0.047 | 4.233 | 2.31E−05 | 0.011 |
| ENSG00000131389 | SLC6A6 | 0.387 | 0.080 | 4.859 | 1.18E−06 | 4.54E−04 | 0.348 | 0.092 | 3.773 | 1.61E−04 | 0.041 |
| ENSG00000181634 | TNFSF15 | 0.330 | 0.084 | 3.922 | 8.78E−05 | 0.011 | 0.338 | 0.075 | 4.523 | 6.09E−06 | 3.76E−03 |
| ENSG00000104327 | CALB1 | 0.995 | 0.278 | 3.582 | 3.40E−04 | 0.028 | 0.821 | 0.174 | 4.710 | 2.47E−06 | 2.18E−03 |
| ENSG00000154153 | RETREG1 | 0.201 | 0.047 | 4.289 | 1.80E−05 | 3.61E−03 | 0.224 | 0.058 | 3.851 | 1.18E−04 | 0.034 |
| ENSG00000204866 | IGFL2 | 0.617 | 0.150 | 4.101 | 4.11E−05 | 6.34E−03 | 0.601 | 0.150 | 4.009 | 6.11E−05 | 0.022 |
Note: Positive log2fold changes represent genes that were overexpressed in colon organoids following additional calcium supplementation. Genes are sorted in ascending order based on the sum of ranks for significance in both right and left colon organoids.
alfcSE, standard error attributed to estimate of log2fold change in gene expression.
aStat, test statistic generated from Wald test in DESeq2.