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. 2022 Jun 22;20(10):1516–1531. doi: 10.1158/1541-7786.MCR-20-1029

Figure 7.

Figure 7. TRAF4 expression correlates positively with pSMAD1/5/8 levels and negatively with the p-p65 level in bladder tumors. A, Regression analysis showing the correlations between the TRAF4 expression level (score) and phospho (p)SMAD1/5/8 scores in patients with bladder cancer. Pearson χ2 test was used to determine the correlations between the TRAF4 and pSMAD1/5/8 scores. B, Regression analysis showing the correlations between the TRAF4 expression level (score) and phospho (p)-p65 score in bladder cancer patients. Pearson χ2 test was used to determine the correlations between the TRAF4 and p-p65 scores. C, Representative images of continuous sections of tissue microarray samples probed with the indicated antibodies using fluorescent IHC. The magnified insets for pSMAD1/5/8 show nuclear staining. Scale bar: 400 μm. D, Schematic representation of TRAF4 signaling dynamics in epithelial-like and mesenchymal-like bladder cancer cells. Ub denotes ubiquitin and P stands for phosphorylation of serine 334.

TRAF4 expression correlates positively with pSMAD1/5/8 levels and negatively with the p-p65 level in bladder tumors. A, Regression analysis showing the correlations between the TRAF4 expression level (score) and phospho (p)SMAD1/5/8 scores in patients with bladder cancer. Pearson χ2 test was used to determine the correlations between the TRAF4 and pSMAD1/5/8 scores. B, Regression analysis showing the correlations between the TRAF4 expression level (score) and phospho (p)-p65 score in bladder cancer patients. Pearson χ2 test was used to determine the correlations between the TRAF4 and p-p65 scores. C, Representative images of continuous sections of tissue microarray samples probed with the indicated antibodies using fluorescent IHC. The magnified insets for pSMAD1/5/8 show nuclear staining. Scale bar: 400 μm. D, Schematic representation of TRAF4 signaling dynamics in epithelial-like and mesenchymal-like bladder cancer cells. Ub denotes ubiquitin and P stands for phosphorylation of serine 334.