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. 2022 Aug 16;82(19):3622–3633. doi: 10.1158/0008-5472.CAN-22-0101

Figure 4.

Figure 4. Histologic assessment of tumor cell death 48 hours following chemo-radiotherapy treatment. Representative sections of A11 (A–F), S2 (I–N), and U87 (Q–V) tumors stained with H&E (A, D, I, L, Q, T). The upper panels show the whole brain section containing the tumor and the lower panels a 10x magnification of part of the tumor area. The sections were co-stained for CC3 (B, E, J, M, R, U) and TUNEL (C, F, K, N, S, V). The percentage of CC3 (G, O, W) and TUNEL (H, P, X) positive cells pretreatment and 48 hours after the completion of treatment is shown for A11 (G, H), S2 (O, P), and U87 (W, X) tumors (n = 4 per group, drug- and untreated). Data are shown as mean ± SD. **, P < 0.01; ***, P < 0.001.

Histologic assessment of tumor cell death 48 hours following chemoradiotherapy treatment. Representative sections of A11 (A–F), S2 (I–N), and U87 (Q–V) tumors stained with hematoxylin and eosin (H&E; A, D, I, L, Q, and T). The top panels show the whole brain section containing the tumor, and the bottom panels show a Multiplication symbol 10 magnification of part of the tumor area. The sections were co-stained for CC3 (B, E, J, M, R, and U) and TUNEL (C, F, K, N, S, and V). The percentage of CC3 (G, O, and W)- and TUNEL (H, P, and X)-positive cells pretreatment and 48 hours after the completion of treatment is shown for A11 (G and H), S2 (O and P), and U87 (W and X) tumors (n = 4 per group, drug treated and untreated). Data are shown as mean ± SD. **, P < 0.01; ***, P < 0.001.