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. 2022 Aug 16;82(19):3622–3633. doi: 10.1158/0008-5472.CAN-22-0101

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©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license.

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Figure 6. DCE MRI measurements of perfusion in A11 [n = 3; (A–C)], S2 [n = 3; (D–F)], and U87 [n = 3; (G–I)] tumors before and after treatment. Representative color intensity maps of mean contrast agent concentration over the first three minutes following injection in A11 (A), S2 (D), and U87 (G) tumors. The locations of the tumors are outlined by dotted white lines. Estimated contrast agent concentration in tumor tissue at the indicated times after intravenous injection before and 48 hours following the last chemo-radiotherapy treatment of A11 (B), S2 (E), and U87 (H) tumors. Data are shown as mean ± SD; *, P < 0.05; ***, P < 0.001. The area under the uptake curve (AUC) showed an increase in contrast agent uptake in S2 tumors (**, P = 0.0024, paired two-tailed t test) following treatment (F), while there were no significant differences in A11 (C) and U87 (I) tumor-bearing animals. Data are presented as mean ± SD. — DCE MRI measurements of perfusion in A11 (n = 3; A–C), S2 (n = 3; D–F), and U87 (n = 3; G–I) tumors before and after treatment. Representative color intensity maps of mean contrast agent concentration over the first three minutes following injection in A11 (A), S2 (D), and U87 (G) tumors. The locations of the tumors are outlined by dotted white lines. Estimated contrast agent concentration in tumor tissue at the indicated times after intravenous injection before and 48 hours following the last chemoradiotherapy treatment of A11 (B), S2 (E), and U87 (H) tumors. Data are shown as mean ± SD; *, P < 0.05; ***, P < 0.001. The area under the uptake curve (AUC) showed an increase in contrast agent uptake in S2 tumors (**, P = 0.0024, paired two-tailed t test) following treatment (F), while there were no significant differences in A11 (C) and U87 (I) tumor-bearing animals. Data are presented as mean ± SD. ns, nonsignificant.