Table 4.
Subgroup analysis for cardiovascular mortality for logRC and RC (continuous variables).
| LogRC | P | p-int | RC, mg/dL | RC, mmol/L | P | p-int | |
|---|---|---|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | HR (95% CI) | |||||
| Age | <0.001 | 0.025 | |||||
| ≥65 years | 9.33 (3.22, 27.09) | <0.001 | 1.01 (1.01, 1.02) | 1.49 (1.22, 1.82) | <0.001 | ||
| <65 years | 0.57 (0.16, 1.95) | 0.369 | 0.99 (0.97, 1.01) | 0.67 (0.31, 1.44) | 0.305 | ||
| Sex | 0.080 | 0.158 | |||||
| Male | 4.63 (1.68, 12.77) | 0.003 | 1.01 (1.00, 1.02) | 1.50 (1.19, 1.87) | 0.001 | ||
| Female | 0.96 (0.21, 4.49) | 0.960 | 1.00 (0.98, 1.02) | 0.93 (0.42, 2.07) | 0.867 | ||
| Diabetes | 0.086 | 0.112 | |||||
| Yes | 5.36 (1.61, 17.82) | 0.006 | 1.01 (1.00, 1.01) | 1.44 (1.17, 1.77) | 0.001 | ||
| No | 1.27 (0.39, 4.15) | 0.692 | 1.00 (0.98, 1.01) | 0.88 (0.45, 1.71) | 0.699 | ||
| Hypertension | 0.803 | 0.705 | |||||
| Yes | 3.08 (1.10, 8.62) | 0.032 | 1.01 (1.00, 1.02) | 1.45 (1.15, 1.82) | 0.002 | ||
| No | 3.39 (0.60, 19.24) | 0.169 | 1.01 (0.99, 1.02) | 1.24 (0.65, 2.36) | 0.510 | ||
| Smoking | 0.530 | 0.632 | |||||
| Yes | 3.41 (1.19, 9.77) | 0.022 | 1.01 (1.00, 1.02) | 1.42 (1.12, 1.80) | 0.004 | ||
| No | 1.97 (0.47, 8.34) | 0.356 | 1.01 (0.99, 1.02) | 1.25 (0.74, 2.12) | 0.408 |
HR, hazard ratio; CI, confidence interval; p-int, p for interaction. Adjusted for age + sex + race + antihypertensive medications + lipid-lowering medications use + systolic blood pressure + coronary heart disease + stroke + smoking.