Table 5.

Hazard ratios (95% confidence interval) and P-value for cardiovascular events of different lipid groups.

	Lipid group		Cardiovascular events, n /Individuals, n		HR (95% CI)		P -value
LDL-C	HDL-C	RC	Male	Female	Male	Female	Male	Female
<130	≥ cutpoint	< cutpoint	73/3647	30/3,678	REF
		≥ cutpoint	36/761	10/764	2.34 (1.29, 4.24)**	1.20 (0.59, 2.42)	0.005	0.618
≥ 130		< cutpoint	31/1552	21/1,327	1.25 (0.68, 2.30)	1.67 (0.97, 2.87)	0.469	0.065
		≥ cutpoint	25/765	18/800	1.47 (0.72, 3.02)	1.92 (1.07, 3.44)*	0.293	0.028
<130	< cutpoint	< cutpoint	15/795	8/1,325	0.82 (0.34, 1.95)	0.61 (0.28, 1.31)	0.648	0.202
		≥ cutpoint	32/1092	25/987	0.80 (0.38, 1.69)	2.49 (1.49, 4.17)**	0.554	0.001
≥ 130		< cutpoint	4/301	6/414	0.91 (0.28, 2.97)	1.40 (0.59, 3.33)	0.871	0.448
		≥ cutpoint	27/655	21/787	2.18 (1.13, 4.21)*	2.19 (1.24, 3.88)**	0.020	0.007

Corresponding to LDL-C clinical cutpoint (130 mg/dL), respective RC cutpoint was 25.7/23.7 mg/dL in male/female group. Respective HDL-C cutpoint was 40/50 mg/dL in male/female group. Adjusted for age + race + antihypertensive medications + lipid-lowering medications use + systolic blood pressure + coronary heart disease + stroke + smoking. ^*P < 0.05, ^**P < 0.01.