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. 2022 Oct 1;35(4):423–432. doi: 10.3344/kjp.2022.35.4.423

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© The Korean Pain Society, 2022

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 4 — (A) The expression of GFAP, p-ERK1/2, and MOR by immunohistochemistry staining in amygdala tissue of rats (magnification: 200×). The positive expressing proteins appeared brown in color. (B) The results showed that GFAP and p-ERK1/2 are significantly up-regulated in group S + IN (*P < 0.050), the expression of MOR is significantly down-regulated in group S + IN (*P < 0.050). There were no significant differences between group IN and group S (**P > 0.050). The expression of GFAP and p-ERK1/2 are significantly up-regulated in group S and group IN (*P < 0.050) compared with the sham group. The expression of MOR is significantly down-regulated in group S and group IN (*P < 0.050) compared with the sham group. The error bars indicate mean ± standard deviation. GFAP: glial fibrillary acidic protein, p-ERK1/2: phosphorylated extracellular regulatory protein kinase, MOR: mu-opioid receptors, S: stress, IN: incision, IOD: integrated optical density.