TABLE 1.
Summary of findings: Associations between subjective cognitive complaints and various outcomes of interest
| Disease stage | |||
|---|---|---|---|
| CU | MCI | Dementia | |
| SCC vs. objective cognition | |||
| Self‐report | + | +/– | – |
| Study partner report | ++ | ++ | ++ |
| Dyad agreement | +/– | ? | – |
| Dyad discrepancy | +/– | ++ | – |
| SCC vs. diagnosis a | |||
| Self‐report | N/A | +/– | – |
| Study partner report | N/A | ++ | ++ |
| Dyad agreement | N/A | +/– | – |
| Dyad discrepancy | N/A | +/– | ++ |
| SCC vs. disease progression a | |||
| Self‐report | N/A | + | – |
| Study partner report | N/A | ++ | ++ |
| Dyad agreement | N/A | + | – |
| Dyad discrepancy | N/A | ++ | ++ |
| SCC vs. AD biomarkers | |||
| Self‐report | +/– | +/– | – |
| Study partner report | + | + | + |
| Dyad agreement | ? | + | – |
| Dyad discrepancy | + | ? | + |
Abbreviations: AD, Alzheimer's disease; CU, cognitively unimpaired; MCI, mild cognitive impairment; SCC, subjective cognitive complaints.
a
Results are shown with CU individuals as the reference value.
+: Positive relationship
++: Robust evidence for positive relationship based on multiple studies
–: Negative relationship
+/–: Conflicting results (showing both positive and negative relationships)
?: Lack of evidence