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. 2022 Sep 20;13:982241. doi: 10.3389/fgene.2022.982241

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Copyright © 2022 Zhao, Zhao, Zhong, Zhang, Yan, Feng and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TISIDB analysis of correlations between PITX1 and PITX2 methylation and immune cells infiltration across human cancers. (A) The relationship between PITX1 methylation and 28 types of TILs across various human cancers. (B) The top six TILs displaying the strongest Spearman’s correlation with PITX1 methylation in HNSC. (C) The relationship between PITX2 methylation and 28 types of TILs across various human cancers. (D) The top six TILs displaying the strongest Spearman’s correlation with PITX2 methylation in HNSC. Act_CD8, activated CD8⁺ T cells; Tcm_CD8, central memory CD8⁺ T cells; Tem_CD8, effector memory CD8⁺ T cells; Act_CD4, activated CD4⁺ T cells; Tcm_CD4, central memory CD4⁺ T cells; Tem_CD4, effector memory CD4⁺ T cells; Tfh, T follicular helper cells; Tgd, gamma delta T cells; Th1, type 1 T helper cells; Th17, type 17 T helper cells; Th2, type 2 T helper cells; Treg, regulatory T cells; Act B, activated B cells; Imm_B, immature B cells; Mem_B, memory B cells; NK, natural killer cells; CD56^bright, CD56^bright NK cells; CD56^dim, CD56^dim NK cells; MDSC, myeloid derived suppressor cells; NKT, natural killer T cells; Act DC, activated dendritic cells; pDC, plasmacytoid DCs; iDC, immature DCs; Mast, mast cells.