TABLE 3.

The expression and methylation levels of PITX1 and PITX2 correlate with ITLs.

	PITX1 expression		PITX2 expression		PITX1 methylation		PITX2 methylation
	r	p	r	p	r	p	r	p
Activated CD8+ T cell (act_CD8)	0.207	1.9e−06	−0.133	0.00243	0.346	5.28e−16	0.357	<2.20e−16
Central memory CD8+ T cell (Tcm_CD8)	−0.06	0.174	0.076	0.0818	0.375	<2.20e−16	−0.065	0.139
Effector memory CD8+ T cell (Tem_CD8)	0.195	7.22e−06	−0.078	0.0744	0.365	9.4e−19	0.343	1.02e−15
Activated CD4+ T cell (Act CD4)	0.117	0.00742	−0.161	0.00023	0.12	0.00629	0.368	<2.20e−16
Central memory CD4+ T cell (Tcm_CD4)	−0.214	8.55e−07	−0.051	0.248	0.393	<2.20e−16	−0.062	0.16
Effector memory CD4+ T cell (Tem_CD4)	−0.029	0.503	−0.028	0.523	0.2	4.26e−06	0.218	5.14e−07
T follicular helper cell (Tfh)	−0.047	0.283	−0.033	0.446	0.478	<2.20e−16	0.203	3.22e−06
Gamma delta T cell (Tgd)	−0.173	7.26e−05	−0.05	0.255	0.442	<2.20e−16	0.006	0.885
Type 1 T helper cell (Th1)	−0.068	0.123	−0.042	0.341	0.437	<2.20e−16	0.27	4.4e−10
Type 17 T helper cell (Th17)	0.307	1.04e−12	−0.136	0.0019	0.091	0.0375	0.371	<2.20e−16
Type 2 T helper cell (Th2)	−0.077	0.0789	−0.034	0.434	0.2	4.52e−06	0.146	0.000843
Regulatory T cell (Treg)	−0.216	6.91e−07	−0.082	0.0617	0.475	<2.20e−16	0.134	0.00225
Activated B cell (act B)	0.148	0.000717	−0.163	0.000195	0.259	<2.20e−16	0.477	<2.20e−16
Immature B cell (Imm_B)	0.118	0.00718	−0.158	0.000294	0.371	<2.20e−16	0.431	<2.20e−16
Memory B cell (Mem_B)	−0.178	4.37e−05	0.019	0.673	0.176	5.36e−05	0.187	1.76e−05
Natural killer cell (NK)	−0.069	0.113	−0.049	0.26	0.318	1.25e−13	0.225	2.27e−07
CD56bright natural killer cell (CD56bright)	0.102	0.0193	−0.005	0.904	0.274	2.28e−10	−0.071	0.107
CD56dim natural killer cell (CD56dim)	0.029	0.51	0.012	0.793	0.113	0.00974	0.007	0.877
Myeloid derived suppressor cell (MDSC)	0.082	0.0626	−0.098	0.025	0.458	<2.20e−16	0.273	2.83e−10
Natural killer T cell (NKT)	−0.223	2.74e−07	−0.154	0.000413	0.391	<2.20e−16	0.184	2.38e−05
Activated dendritic cell (Act_DC)	0.108	0.0135	−0.08	0.0664	0.336	3.66e−15	0.223	2.68e−07
Plasmacytoid dendritic cell (pDC)	−0.041	0.353	−0.092	0.0363	0.276	1.72e−10	0.091	0.0376
Immature dendritic cell (iDC)	0.196	6.83e−06	0.072	0.101	0.158	0.000293	0.126	0.00383
Macrophage (macrophage)	−0.1	0.023	−0.041	0.35	0.425	<2.20e−16	0.188	1.59e−05
Eosinophil (eosinophil)	0.041	<2.20e−16	−0.056	0.203	0.242	2.39e−08	0.249	9.54e−09
Mast cell (mast)	−0.028	0.525	−0.022	0.614	0.227	1.37e−10	0.186	2e−05
Monocyte (monocyte)	0.038	0.389	−0.11	0.0118	0.396	<2.20e−16	0.154	0.000438
Neutrophil (neutrophil)	0.091	0.0371	0.041	0.346	0.239	3.41e−08	−0.021	0.637

Bold value means statistically significant.