Table 2.

AQP1 and AQP4 in iNPH.

	AQP1	AQP4
Positional distribution in the nervous system	The top and outer parts of the vein epithelial cells	Plasma membrane, glial boundary membrane and ependyma of foot process of astrocytes around capillaries
Effects on cerebrospinal fluid circulation	The positional distribution of the top AQP1 facilitates cross-cell transport of water molecules during the development of cerebrospinal fluid	Accumulated cerebrospinal fluid be absorbed into the bloodstream through AQP4-dependent transcellular pathway
In the genetic knockout animal model	Cerebrospinal fluid production is reduced and intracranial pressure is reduced	The cerebrospinal fluid increases, intracranial pressure increases, and the permeability of water in brain tissue is greatly reduced
In iNPH patients	Abnormally elevated	Abnormally decreased
Mechanisms that act in brain tissue in iNPH patients	Mostly like other types of hydrocephalus, the polarity distribution of AQP1 is protected from extinction	Mostly unlike other types of hydrocephalus patients, may be blocked lymphatic circulation and hyperplication of glial cells
Expression and adjustment	Multi-level adjustment	MicroRNAs, phosphorylation, heavy metal ions, small molecule inhibitors

AQP1, aquaporin 1; AQP4, aquaporin 4.