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. 2022 Sep 20;13:995974. doi: 10.3389/fimmu.2022.995974

Figure 10.

Figure 10

SCAMP5 is highly expressed in patients with sepsis and has significant diagnostic value. (A) Expression of hub genes in the control and sepsis samples in GSE26378. SCAMP5, RNF175, FBXO6 and TBL2 were significantly up-regulated in the sepsis patients (P < 0.05 by the two-sided t test. (B) ROC curve showing predictive value of SCAMP5 for sepsis in GSE26378 with AUC = 0.757. (C) Expression of hub genes in the control and sepsis samples in GSE54514. SCAMP5 and SDE2L1 were significantly up-regulated in the sepsis patients (*P < 0.05 by the two-sided t test). (D) ROC curve showing predictive value of SCAMP5 for sepsis in GSE54514 with AUC = 0.637. (E) SCAMP5 mRNA levels in the PBMCs from healthy controls and sepsis patients as determined by qRT-PCR. Mean ± SD (n = 5), **P < 0.01. (F) SCAMP5 protein levels in the PBMCs from healthy controls and sepsis patients. (G) Single-cell sequencing database results showing that SCAMP5 is expressed in the dendritic cells.