TABLE 2.
A comparison of eukaryotic client proteins of nuclear biomolecular condensates. Percentage of alignments were generated using NCBI protein or nucleotide BLAST alignment tools.
| Client Protein | Condensate | Conservation |
|---|---|---|
| Nucleophosmin | Nucleolus | H. sapiens (294aa) |
| G. gallus (294aa)—68.12% | ||
| D. melanogaster (156aa)—34.94% | ||
| S. cerevisiae—no homolog | ||
| ARF | Nucleolus | H. sapiens (133aa) |
| G. gallus (60aa)—0% | ||
| D. melanogaster- no homolog | ||
| S. cerevisiae—no homolog | ||
| p53 | Nucleolus, Nucleolar aggresome | H. sapiens (393aa) |
| G. gallus (367aa)—52.47% | ||
| D. melanogaster (334aa)—24.31% | ||
| S. cerevisiae—no homolog | ||
| EIF4B | A-body | H. sapiens (611aa) |
| G. gallus (596aa)—67.37% | ||
| D. melanogaster (392aa)—28.77% | ||
| S. cerevisiae (436aa)—32.18% | ||
| CDC73 | A-body | H. sapiens (531aa) |
| G. gallus (531aa)—97.74% | ||
| D. melanogaster (538aa)—57.84% | ||
| S. cerevisiae (393aa)—26.89% | ||
| NONO | Paraspeckles | H. sapiens (471aa) |
| G. gallus (473aa)—84.02% | ||
| D. melanogaster—nonA (700aa)—43.90% | ||
| C. elegans (374aa)—45.16% | ||
| S. cerevisiae—Pab1p (571aa)—23.81% | ||
| SFPQ | Paraspeckles | H. sapiens (707aa) |
| G. gallus (615aa)—94.03% | ||
| D. melanogaster—nonA (700aa)—46.50% | ||
| S. cerevisiae—Hrp1p (534aa)—28.66% | ||
| HSF1 | Nuclear stress body | H. sapiens (529aa) |
| G. gallus (491aa)—73.89% | ||
| D. melanogaster (715aa)—49 .08% | ||
| S. cerevisiae (833aa)—30.60% | ||
| DAXX | PML body | H. sapiens (740aa) |
| G. gallus (738aa)—40 .85% | ||
| D. melanogaster—(1620aa)—26.98% | ||
| S. cerevisiae—no homolog |