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. 2022 Sep 20;13:988685. doi: 10.3389/fimmu.2022.988685

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Copyright © 2022 Penrice-Randal, Dong, Shapanis, Gardner, Harding, Legebeke, Lord, Vallejo, Poole, Brendish, Hartley, Williams, Wheway, Polak, Strazzeri, Schofield, Skipp, Hiscox, Clark and Baralle

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Differential expression of top genes in the top 3 pathways between patients admitted to ICU and not admitted to ICU of the training set. Connections represent known gene interactions according to STRING-db. (A) SNX2 - controlling epidermal growth factor receptor (EGFR) presentation, (B) ACAA1-peak pathway, representing peroxisome proliferator-activated receptor alpha (PPAR-α) signalling, (C) FAM89B-peak pathway, mediating transforming growth factor beta (TGF-β) signalling. Pathways and genes identified by topological data analysis, TopMD.