Table 3.

Univariate and multivariate Cox analyses of the factors for overall survival in colon cancer.

Variable	Univariate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
Age (years)	1.016 (1.011-1.020)	<0.001	1.031 (1.026-1.036)	<0.001
Sex
Male	Reference		NI
Female	1.016 (0.915-1.129)	0.766
Years
2008-2013	Reference		NI
2014-2018	0.984 (0.881-1.099)	0.773
Location
Left side	Reference		Reference
Right side	1.181 (1.063-1.312)	0.002	1.145 (1.027-1.278)	0.015
Surgical procedures
Open	Reference		Reference
Laparoscopic	0.851 (0.716-1.011)	0.067	0.932 (0.777-1.119)	0.452
Neoadjuvant therapy
No	Reference		Reference
Yes	2.519 (2.058-3.083)	<0.001	1.642 (1.310-2.058)	<0.001
Histologic type
Adenocarcinoma	Reference		Reference
Mucinous	1.253 (1.090-1.440)	0.001	1.174 (1.001-1.376)	0.049
Signet ring cell	2.762 (2.106-3.622)	<0.001	1.863 (1.378-2.521)	<0.001
Unknown	/		/
Differentiation
Moderate	Reference		Reference
Poor	1.839 (1.647-2.053)	<0.001	1.256 (1.106-1.425)	<0.001
Well	0.666 (0.423-1.050)	0.080	1.306 (0.820-2.082)	0.261
Unknown	/		/
T stage
Tx, 0-2	Reference		Reference
T3	2.550 (2.053-3.168)	<0.001	1.228 (0.969-1.555)	0.089
T4	2.995 (2.455-3.654)	<0.001	1.421 (1.143-1.765)	0.002
N stage
N0	Reference		Reference
N1	2.693 (2.361-3.071)	<0.001	1.885 (1.633-2.177)	<0.001
N2	5.735 (5.020-6.551)	<0.001	3.077 (2.616-3.618)	<0.001
M stage
0	Reference		Reference
1	6.471 (5.811-7.205)	<0.001	4.469 (3.971-5.030)	<0.001
Perineural invasion
Negative	Reference		Reference
Positive	2.256 (2.023-2.515)	<0.001	1.332 (1.183-1.500)	<0.001
Vascular invasion
Negative	Reference		Reference
Positive	2.736 (2.464-3.038)	<0.001	1.279 (1.131-1.446)	<0.001
CRM
Negative	Reference		Reference
Positive	4.199 (3.295-5.352)	<0.001	2.050 (1.584-2.653)	<0.001

CRM, circumferential resection margin.