FIGURE 6.

Analysis of somatic mutations of the Brca1 locus in the mammary carcinoma of the Brca1 ^L63X/+ rats. (A) Retention of heterozygosity as revealed by allele‐specific quantitative PCR. The occupancy of the Brca1 ^L63X allele was ~50% in normal kidney tissues and mammary carcinomas from rats that were unexposed (0 Gy) and irradiated (2 Gy) at 3 or 7 weeks of age. (B) Summarized results of the target sequencing of the Brca1 locus. MNU, 1‐methyl‐1‐nitrosourea; N, number of tumors analyzed. See Table S1 for detail