TABLE 1.
Classification definitions and patient characteristics of induced pluripotent stem cell lines derived from patients with breast cancer
| Line code | Age (years) | Sex | LVEF (%) | Evaluation of risk factors | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | Minimum | Decline range | Age | High BMI | AF | HT | DM | Smoker | PMH | Cumulative dose anthracycline | Post RTx | BNP ≥100 pg/ml | |||
| >65 years | >30 kg/mg2 | ||||||||||||||
| SP1 | 58 | F | 69 | 30 | 39 | − | − | − | − | − | − | − | 360 | − | 8.5 |
| SP2 | 63 | F | 75 | 33 | 42 | − | − | − | − | − | − | − | 389.2 | − | 30 |
| SP3 | 65 | F | 66 | 14 | 52 | − | − | − | − | − | − | − | 400 | − | 41 |
| NP1 | 57 | F | 70 | 60 | − | − | − | − | − | − | − | − | 300 | − | 44 |
| NP2 | 70 | F | 65 | 63 | − | + | − | − | − | + | − | − | 450 | − | 57 |
| NP3 | 50 | F | 68 | 64 | − | − | − | − | − | − | − | − | 350 | − | 23 |
Abbreviations: AF, atrial fibrillation; BMI, body mass index; BNP, brain natriuretic peptide; DM, diabetes mellitus; F, female; HT, hypertension; LVEF, left ventricular ejection fraction; M, male; NP, noncardiotoxic patient group; PMH, past cardiovascular‐related disease history; RTx, radiotherapy; SP, severely cardiotoxic patient group.