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. 2022 Sep 20;13:966022. doi: 10.3389/fneur.2022.966022

Table 2.

Univariate and multivariate logistic regression analysis of factors for the distribution of atherosclerotic stenosis.

Variables Intracranial stenosis alone Extracranial stenosis alone Combined intracranial and extracranial stenosis
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
OR (95%CI) p OR (95%CI) p OR (95%CI) p OR (95%CI) p OR (95%CI) p OR (95%CI) p
Sex, M 1.00 (0.67–1.49) 0.999 2.38 (1.47–3.84) <0.001 2.45 (1.41–4.27) 0.002 1.71 (1.13–2.60) 0.011 1.86 (1.10–3.14) 0.020
Age 1.01 (0.99–1.03) 0.467 1.07 (1.05–1.11) <0.001 1.07 (1.03–1.10) <0.001 1.06 (1.04–1.09) <0.001 1.07 (1.04–1.10) <0.001
Hypertension 1.84 (1.24–2.72) 0.002 1.43 (0.94–2.17) 0.094 2.03 (1.31–3.14) 0.002 1.43 (0.87–2.34) 0.115 2.53 (1.69–3.80) <0.001 1.99 (1.24–3.18) 0.004
Diabetes 2.45 (1.44–4.16) 0.001 2.23 (1.28–3.87) 0.005 2.76 (1.57–4.84) <0.001 2.44 (1.30–4.60) 0.006 4.10 (2.42–6.94) <0.001 3.62 (2.05–6.41) <0.001
Stroke 1.44 (0.34–2.33) 0.139 1.55 (0.592–2.62) 0.097 1.50 (0.92–2.44) 0.102
Smoking 0.89 (0.59–1.35) 0.586 1.07 (0.68–1.67) 0.778 1.19 (0.79–1.80) 0.41
WBC 1.09 (0.99–1.19) 0.081 1.04 (0.93–1.17) 0.454 1.16 (1.04–1.29) 0.008 0.99 (0.84–1.17) 0.912
Platelet 1.00 (1.00–1.00) 0.606 1.00 (0.99–1.00) 0.343 1.00 (1.00–1.01) 0.048 1.00 (1.00–1.01) 0.064
Neutrophil 1.22 (1.08–1.38) 0.001 1.19 (1.03–1.38) 0.017 1.32 (1.15–1.52) <0.001
Lymphocyte 0.48 (0.34–0.69) <0.001 0.45 (0.30–0.66) <0.001 0.55 (0.39–2.60) 0.001
Monocyte 0.98 (0.35–0.69) 0.971 1.62 (0.49–5.28) 0.430 2.82 (0.90–2.44) 0.076
TC 0.92 (0.78–1.18) 0.624 0.84 (0.69–1.03) 0.090 0.98 (0.83–1.16) 0.802
TG 1.00 (0.87–1.15) 0.955 0.84 (0.67–1.05) 0.120 1.02 (0.87–1.19) 0.843
HDL 0.36 (0.18–0.73) 0.005 0.36 (0.17–0.76) 0.008 0.37 (0.15–0.89) 0.027 0.43 (0.15–1.27) 0.128 0.22 (0.10–0.48) <0.001 0.15 (0.04–0.53) 0.003
LDL 0.95 (0.76–1.18) 0.624 0.92 (0.72–1.17) 0.449 1.05 (0.85–1.30) 0.643
Lpa 1.00 (1.00–1.00) 0.253 1.00 (1.00–1.00) 0.032 1.00 (1.00–1.00) 0.096 1.00 (1.00–1.00) 0.016 1.00 (1.00–1.00) 0.017
MHR 1.79 (0.80–3.99) 0.157 1.95 (0.75–5.04) 0.168 3.94 (1.61–9.62) 0.003 0.51 (0.11–2.27) 0.375
NLR 1.51 (1.25–1.82) <0.001 1.54 (1.27–1.85) <0.001 1.60 (1.29–1.98) <0.001 1.56 (1.25–1.96) <0.001 1.64 (1.34–2.00) <0.001 1.61 (1.28–2.03) <0.001

WBC, white blood cell; TC, total cholesterol; TG, triglyceride; HDL, high-density lipoprotein; LDL, low-density lipoprotein; Lpa, Lipoprotein(a); MHR, monocyte to HDL ratio; NLR, neutrophil-to-lymphocyte ratio; OR, odds ratio; 95% CI, 95% confidence interval; multivariable analysis: adjusted for factors with p < 0.05 in univariate analysis, neutrophil and lymphocyte were not included due to multicollinearity. The bold values indicate the significant values (p < 0.05).