Table 4.

Concentrations of markers of complement and endothelial cell activation and inflammation on admission according to the composite outcome of admission to the intensive care unit or death at 30 days in cases and controls.

	COVID-19, composite outcome			Controls, composite outcome
Variables	Yes (n=41)	No (n=112)	P value	Yes (n=27)	No (n=139)	P value
C5a, ng/ml	4.46 (3.31 – 7.61)	2.52 (1.38 – 5.55)	0.001	1.46 (0.80 – 2.16)	0.82 (0.27 – 1.76)	0.024
sC5b-9, ng/ml	1244 (767 – 1929)	1110 (709 – 1533)	0.119	955 (783 – 1131)	1000 (733 – 1333)	0.79
E-selectin, ng/ml	30.9 (19.7 – 47.9)	24.0 (17.4 – 34.1)	0.059	36.8 (25.5 – 59.2)	29.8 (21.9 – 41.6)	0.064
Galectin-3, ng/ml	12.1 (10.3 – 15.9)	8.1 (6.5 – 11.3)	<0.001	10.9 (8.3 – 14.2)	8.0 (6.7 – 10.5)	0.005
ICAM-1, ng/ml	486 (377 – 662)	366 (301 – 472)	<0.001	452 (380 – 614)	358 (289 – 478)	0.003
VCAM-1, ng/ml	1323 (1029 – 1699)	835 (654 – 1329)	<0.001	863 (678 – 1340)	591 (483 – 797)	0.001
CRP, mg/L	112 (48 – 163)	16.9 (1.5 – 52.3)	<0.001	57.3 (30.4 – 127.4)	3.2 (0.6 – 33.0)	<0.001
D-Dimer, mg/L	1.16 (0.53 – 2.84)	0.52 (0.34 – 1.08)	0.002	1.41 (0.56 – 4.89)	0.37 (0.29 – 0.89)	<0.001
Ferritin, µg/L	1200 (445 – 2055)	351 (151 – 633)	<0.001	256 (115 – 865)	161 (80 – 310)	0.039

Median (interquartile range), values are shown in bold in case of significant difference.

CRP, C-reactive protein.