Table 1.
Summary of differentially expressed ferroptosis-related genes in cardiotoxicity induced by the anticancer drug regorafenib in lines A, B, D, and E.
| Gene | Line A | Line B | Line D | Line E | ||||
|---|---|---|---|---|---|---|---|---|
| Log2FC | P.adj | Log2FC | P.adj | Log2FC | P.adj | Log2FC | P.adj | |
| NOX4 | -1.28728 | 0.0026744 | -1.8955291 | 2.47E-10 | -1.612354 | 0.0002549 | -1.646528 | 4.36E-05 |
| DDIT4 | -1.10465 | 0.0286193 | -1.6882671 | 1.04E-06 | -1.205564 | 9.50E-11 | -1.074215 | 0.001506141 |
| GDF15 | 1.3054065 | 0.0002622 | 2.39358373 | 4.40E-20 | 2.5868351 | 1.46E-17 | 2.768344 | 2.79E-26 |
| SLC3A2 | 1.677388 | 2.93E-05 | 2.91411253 | 1.32E-36 | 2.4279102 | 8.89E-06 | 3.524854 | 4.99E-72 |
| MT1G | 2.8172485 | 0.0286193 | 2.71673009 | 2.92E-09 | 2.6578518 | 0.0003305 | 1.73884 | 0.002175718 |
| ATF3 | 3.0720072 | 2.01E-15 | 3.82781296 | 2.45E-28 | 2.2034991 | 6.38E-05 | 3.788277 | 8.23E-23 |
| PLIN2 | 3.2399218 | 3.24E-32 | 3.48984679 | 2.01E-114 | 2.7328507 | 3.70E-05 | 3.000006 | 5.40E-38 |