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. 2022 Sep 20;10:958181. doi: 10.3389/fpubh.2022.958181

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Copyright © 2022 Sisto, Moleti, Capone, Sanjust, Cerini, Tranfo, Massini, Buscema, Buscema and Chiarella.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Left: sPLS-DA for normal-hearing subjects (green points and arrows) and impaired subjects (red), sorted according to their mean audiometric hearing (top) and DPOAE (bottom) level, considering all 56 differentially expressed microRNAs. The two groups are well separated. Right: biplot representation of the original variables in the 2d space of the transformed variables. Only the microRNAs with a correlation higher than 0.75 are shown by the black arrows. The blue arrows represent the direction of maximal discrimination between the two groups.