Table 2.
Unconditional logistic multiple regression model of risk and protection factors for TB and for distinct TB clinical presentations according to selected inflammasome SNP genetic profiles.
| Gene SNP (rs) | Genotypes, alleles and haplotypes | PLWH | Site of TB | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| With TB N=88 | Without TB N=24 | aORa | 95%CI | P-valueb | PTB N=63 | EPTB N=49 | aORa | 95%CI | P-valueb | ||
| IL-1β rs1143634 | G/G | 62 (70.45%) | 17 (85%) | Ref | 43 (68.25%) | 35 (71.43%) | Ref | ||||
| A/A | 2 (2.27%) | 1 (5%) | 1.08 | 0.05-24.34 | 0.961 | 1 (1.59%) | 1 (2.04%) | 1.3 | 0.08-22.29 | 0.857 | |
| G/A | 24 (27.27%) | 2 (10%) | 5.5 | 1.04-29.02 | 0.044 | 19 (30.16%) | 13 (26.53%) | 0.64 | 0.26-1.61 | 0.346 | |
| G | 148 (84.09%) | 36 (90%) | Ref | 0.094 | 105 (83.33%) | 83 (84.69%) | |||||
| A | 28 (15.91%) | 4 (10%) | 1.14 | 0.98-1.33 | 21 (16.67%) | 15 (15.31%) | 0.94 | 0.78-1.12 | 0.490 | ||
| Non-Carrier-G | 2 (2.27%) | 1 (5%) | Ref | 1 (1.59%) | 1 (2.04%) | ||||||
| Carrier-G | 86 (97.73%) | 19 (95%) | 1.28 | 0.07-23.73 | 0.870 | 62 (98.41%) | 48 (97.96%) | 0.68 | 0.04-11.57 | 0.791 | |
| Non-Carrier-A | 62 (70.45%) | 17 (85%) | Ref | 43 (68.25%) | 35 (71.43%) | ||||||
| Carrier-A | 26 (29.55%) | 3 (15%) | 4.22 | 0.97-18.42 | 0.055 | 20 (31.75%) | 14 (28.57%) | 0.68 | 0.28-1.65 | 0.388 | |
|
NLPR3
rs4612666 |
C/C | 38 (45.24%) | 6 (30%) | Ref | 31 (51.67%) | 19 (41.3%) | Ref | ||||
| C/T | 35 (41.67%) | 12 (60%) | 0.31 | 0.09-1.04 | 0.057 | 26 (43.33%) | 18 (39.13%) | 0.98 | 0.4-2.39 | 0.965 | |
| T/T | 11 (13.1%) | 2 (10%) | 0.63 | 0.1-3.94 | 0.618 | 3 (5%) | 9 (19.57%) | 6.76 | 1.26-36.23 | 0.026 | |
| C | 111 (66.07%) | 24 (60%) | Ref | 88 (73.33%) | 56 (60.87%) | Ref | |||||
| T | 57 (33.93%) | 16 (40%) | 0.93 | 0.83-1.05 | 0.223 | 32 (26.67%) | 36 (39.13%) | 1.15 | 0.99-1.34 | 0.061 | |
| Non-Carrier-C | 11 (13.1%) | 2 (10%) | Ref | 3 (5%) | 9 (19.57%) | Ref | |||||
| Carrier-C | 73 (86.9%) | 18 (90%) | 0.89 | 0.16-4.94 | 0.897 | 57 (95%) | 37 (80.43%) | 0.15 | 0.03-0.75 | 0.021 | |
| Non-Carrier-T | 38 (45.24%) | 6 (30%) | Ref | 31 (51.67%) | 19 (41.3%) | Ref | |||||
| Carrier-T | 46 (54.76%) | 14 (70%) | 0.36 | 0.11-1.14 | 0.082 | 29 (48.33%) | 27 (58.7%) | 1.44 | 0.63-3.3 | 0.383 | |
|
NLRP3
rs10754558 rs1539019 rs4612666 rs3806268 rs35829419 |
CCTGC | 25 (14.88%) | 9 (22.5%) | 0.58 | 0.16-2.19 | 0.423 | 6 (5.26%) | 15 (17.05%) | 4.99 | 1.33-18.71 | 0.017 |
|
CARD8
rs2043211 rs6509365 |
AG | 4 (2.27%) | 4 (10%) | 0.17 | 0.03-0.81 | 0.026 | 4 (3.17%) | 2 (2.04%) | 0.52 | 0.09-3.05 | 0.467 |
aOdds ratios were adjusted by skin color, education, site of tuberculosis, HIV transmission route, and CD8 count. bP-values were calculated using the unconditional logistic regression model. Associations were considered significant with a value of P < 0.05. N, number of individuals in each group; TB, tuberculosis; PLWH, people living with HIV; aOR, adjusted odds ratio; 95% CI, 95% confidence interval; Ref, Reference; PTB, Pulmonary TB; EPTB, Extrapulmonary TB, A, T, G, and C = each allele count, irrespective of the genotype. Carrier-A = total of genotypes with the A allele, Carrier-T = total of genotypes with T allele, Carrier-C = total of genotypes with the C allele, Carrier-G = total of genotypes with the G allele, Non-Carrier-A = total of genotypes without the A allele, Non-Carrier-T = total of genotypes without the T allele, Non-Carrier-C = total of genotypes without the C allele, Non-Carrier-G = total of genotypes without the G allele. Bold indicate statistically significant results.