Table 3.
Unconditional logistic multiple regression model of risk and protection factors for TB-HIV/IRIS among TB-HIV individuals.
| GeneSNP (rs) | Genotypes, alleles and haplotypes | TB-HIV individuals | aORa (CI95%) | P-valueb | |
|---|---|---|---|---|---|
| Without IRIS (N =77) | With IRIS (N = 11) | ||||
|
CARD8
rs2043211 |
A/A | 43 (56.58%) | 10 (90.91%) | Reference | |
| A/T | 25 (32.89%) | 1 (9.09%) | 0.02 (0-0.73) | 0.033 | |
| T/T | 8 (10.53%) | 0 (0%) | NC | NC | |
| A | 111 (73.03%) | 21 (95.45%) | Reference | ||
| T | 41 (26.97%) | 1 (4.55%) | 0.9 (0.81-1) | 0.060 | |
| Non Carrier-A | 8 (10.53%) | 0 (0%) | Reference | ||
| Carrier-A | 68 (89.47%) | 11 (100%) | NC | NC | |
| Non Carrier-T | 43 (56.58%) | 10 (90.91%) | Reference | ||
| Carrier-T | 33 (43.42%) | 1 (9.09%) | 0.02 (0-0.67) | 0.029 | |
|
CARD8
rs6509365 |
A/A | 40 (51.95%) | 9 (81.82%) | Reference | |
| A/G | 29 (37.66%) | 2 (18.18%) | 0.13 (0.01-1.21) | 0.073 | |
| G/G | 8 (10.39%) | 0 (0%) | NC | NC | |
| A | 109 (70.78%) | 20 (90.91%) | Reference | ||
| G | 45 (29.22%) | 2 (9.09%) | 0.93 (0.84-1.03) | 0.175 | |
| Non Carrier-A | 8 (10.39%) | 0 (0%) | Reference | ||
| Carrier-A | 69 (89.61%) | 11 (100%) | NC | NC | |
| Non Carrier-G | 40 (51.95%) | 9 (81.82%) | Reference | ||
| Carrier-G | 37 (48.05%) | 2 (18.18%) | 0.12 (0.01-1.08) | 0.058 | |
|
AIM2
rs2276405 |
C/C | 72 (97.3%) | 9 (90%) | Reference | |
| C/T | 2 (2.7%) | 1 (10%) | 61.06 (1.62-2294.92) | 0.026 | |
| C | 146 (98.65%) | 19 (95%) | Reference | ||
| T | 2 (1.35%) | 1 (5%) | 1.49 (1-2.22) | 0.050 | |
| Non Carrier-C | 74 (100%) | 74 (100%) | Reference | ||
| Carrier-C | 10 (100%) | 10 (100%) | NC | NC | |
| Non Carrier-T | 72 (97.3%) | 9 (90%) | Reference | ||
| Carrier-T | 2 (2.7%) | 1 (10%) | 61.06 (1.62-2294.92) | 0.026 | |
|
CARD8
rs2043211 rs6509365 |
TG | 42 (27.27%) | 1 (4.55%) | 0.07 (0.01-0.81) | 0.033 |
aOdds ratios were adjusted by skin color, education, site of tuberculosis, HIV transmission route, and CD8 count. bP-values were calculated using the unconditional logistic regression model. Associations were considered significant with a value of P < 0.05. N, number of individuals in each group; TB, tuberculosis; aOR, adjusted odds ratio; 95% CI, 95% confidence interval. A, T, G, and C = each allele count, irrespective of the genotype. Carrier-A = total of genotypes with the A allele, Carrier-T = total of genotypes with T allele, Carrier-C = total of genotypes with the C allele, Carrier-G = total of genotypes with the G allele, Non-Carrier-A = total of genotypes without the A allele, Non-Carrier-T = total of genotypes without the T allele, Non-Carrier-C = total of genotypes without the C allele, Non-Carrier-G = total of genotypes without the G allele. NC, not calcuated. Bold indicate statistically significant results.