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. 2022 Sep 20;12:912016. doi: 10.3389/fonc.2022.912016

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Copyright © 2022 Huang, Cheng, Mo, Ru, Mo and Yan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of clinical data of cohorts: (A–D) Comparison of the serology of folate receptor plus circulating tumor cells (FR+CTC), heat shock protein 90 (HSP90), CEA, and CA199 levels between colorectal cancer patients with and without liver metastasis. The data are presented as mean ± standard error of the mean (SEM). Heatmap expression matrix of serological marker correlations in non-metastatic (E) and metastatic colorectal cancers (F). “*” Represents the p-value of the two groups after statistical test, * represents p<0.05, ** represents p<0.01, *** represents p<0.001, and **** represents p<0.0001.