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. 2022 Sep 20;13:979277. doi: 10.3389/fimmu.2022.979277

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Copyright © 2022 Polakova, Kauter, Ismagambetova, Didona, Solimani, Ghoreschi, Hertl, Möbs and Hudemann

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Induction of CD154 expression by Dsg3-specific T cell epitopes. (A) Summary of Dsg3-specific epitopes used for ex vivo stimulation. (B) Relative frequencies of CD154 expression in CD4+ T cells upon ex vivo stimulation with Dsg3-derived peptides (P1, P2, P3, P4) (PV n=11; HC n=14). (C) Relative frequency of CD154 expression out of CD4+ T cells upon ex vivo stimulation with Dsg3-derived peptide P2 and Dsg3 in PV patients (PV n=11).