FIGURE 4.

Metformin changes the relative abundance of bacterial genera. The effect size (log2 fold change) is shown for each bacterial genus, shown with the family name, that was significantly different between 0 mg/kg and 75 mg/kg metformin (pink circles; positive log2 fold change is more abundant in 75 mg/kg), between 25 and 75 mg/kg metformin (green triangles; positive log2 fold change in more abundant in 75 mg/kg), or between 40 and 60 weeks of age (blue squares; positive log fold change is more abundant at 60 weeks). The log2 fold change is shown above each point.