Extended Data Table 1.

Enrolled donors’ demographics.

2–4 weeks after infection/2nd vaccine dose	Dating of SARS-CoV-2 infection	Figure	Nr.	Females	Males	Age (average, range)
Wild type SARS-CoV-2-infected convalescent			29	10	19	56, 34–73
Ospedale Luigi Sacco	Mar-Apr 2020	2b	11	1	10	56, 34–73
Swiss volunteers	Mar 2020	2b	1		1	52, 52–52
HAARVI (University of Washington)	Mar-Apr 2020	2a	17	9	8	51, 25–78
Previously infected BNT162b2-vaccinated			29	19	10	39, 26–56
Clinica Luganese Moncucco	Mar-Nov 2020	2b	4	3	1	38, 27–54
Ente Ospedaliero Cantonale (EOC)	Mar 2020-Jan 2021	2b	18	14	4	39, 26–56
EOC, dialysis pts	Mar 2020-Jan 2021	2c	7	2	5	69, 48–87
Naïve BNT162b2-vaccinated			99	49	50	43, 24–67
Clinica Luganese Moncucco		2b	7	4	3	42, 28–50
Ente Ospedaliero Cantonale (EOC)		2b	18	13	5	43, 24–67
EOC, dialysis pts		2c	55	22	33	74, 29–97
HAARVI (University of Washington)		2a	17	10	7	45, 22–76
Naïve mRNA-1273-vaccinated			40	25	15
Innovative Research, Novi Michigan (1 week after 2nd dose)		2b	20	14	6	58, 34–74
EOC, dialysis pts		2c	8	2	6	85, 81–92
HAARVI (University of Washington)		2a	14	9	5	47, 23–79
Naïve ChAdOx1-vaccinated
INGM, Ospedale Maggio Policlinico		2a	17	13	4	38, 29–51
Naïve Sputnik V-vaccinated
Hospital de Clínicas José de San San Martin, Buenos Aires		2a	11	7	4	42, 30–58
Naïve BBIBP-CorV-vaccinated
Aga Khan University		2a	13	9	4	30, 25–39
1–19 weeks after 1st vaccine dose			Nr.	Females	Males	Age (average, range)
Naïve Ad26.COV2.S-vaccinated
HAARVI (University of Washington)		2a	12	6	6	33, 23–60
Total			250	138	112