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. 2022 Oct 3;19:79. doi: 10.1186/s12987-022-00374-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Characterization of anti-hTfR Nb188 in TfR binding and shuttling over the BBB. A Binding kinetics of Nb62 and Nb188 to immobilized mTfR and hTfR, respectively, were determined by BLI using the Octet system. B TfR hAPI KI mice body temperature measurements after 250 nmol/kg intravenous injections of the indicated VHH fused to NT(8-13). Bar graphs represent mean ± SEM (n = 3 per group). Statistical test: two-way ANOVA with repeated measures and Sidak’s multiple comparisons test. (significant time*treatment interaction effect ****p < 0.0001)