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. 2022 Oct 3;19:79. doi: 10.1186/s12987-022-00374-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Effect on Aβ_1–40 levels after systemic dosing with anti-human TfR/BACE1 antibody. Quantification of Aβ_1–40 concentrations in TfR hAPI KI mouse plasma A and brain B 24 h after an intravenous injection of PBS, 1A11AM-aGFP (167 nmol/kg) or 1A11AM-Nb188 (high dose: 167 nmol/kg; low dose: 16.7 nmol/kg). Bar graphs represent mean ± SEM (n = 3 per group). Statistical test: one-way ANOVA with Dunnet’s multiple comparisons test compared to PBS injected mice. (*p < 0.05, **p < 0.01, ****p < 0.0001)