Table 2.

Summary of global and component ratings of each study

	Selection bias	Study design	Blinding	Data collection method	Withdrawals and dropouts	Global rating
Sativex spray
Alessandria, 2020 [9]	Moderate	Moderate	Weak	Strong	Weak	Weak
Aragona, 2009 [22]	Moderate	Strong	Moderate	Strong	Strong	Strong
Cooper, 2017 [23]	Weak	Strong	Moderate	Strong	Strong	Moderate
Rog, 2005 [14]	Moderate	Strong	Moderate	Strong	Strong	Strong
Vachová, 2014 [15]	Moderate	Strong	Moderate	Strong	Strong	Strong
Wade, 2004 [24]	Moderate	Strong	Moderate	Moderate	Strong	Strong
Russo, 2016 [25]	Moderate	Moderate	Weak	Strong	Strong	Moderate
Castelli, 2018 [26]	Weak	Moderate	Weak	Strong	Weak	Weak
Epidiolex
Martin, 2019 [17]	Moderate	Moderate	Weak	Strong	Weak	Weak
Metternich, 2020 [27]	Moderate	Moderate E	Weak	Strong	Strong	Moderate
Other spray
Almog, 2020 [28]	Moderate	Strong	Moderate	Strong	Strong	Strong
Wade, 2003 [29]	Weak	Strong	Moderate	Moderate	Strong	Moderate
Gelatin capsules
Müller-Vahl, 2001 [30]	Weak	Strong	Moderate	Strong	Strong	Moderate
Müller-Vahl, 2003 [31]	Weak	Moderate	Moderate	Strong	Strong	Moderate
Vaney, 2004 [16]	Moderate	Strong	Moderate	Strong	Moderate	Strong
Smocked or vaped
Corey-Bloom, 2012 [11]	Weak	Strong	Moderate	Strong	Strong	Moderate
Wallace, 2015 [12]	Moderate	Strong	Moderate	Strong	Strong	Strong
Wilsey, 2008 [13]	Moderate	Strong	Moderate	Strong	Strong	Strong
Wilsey, 2013 [32]	Moderate	Strong	Moderate	Strong	Strong	Strong
Abdallah, 2018 [33]	Moderate	Strong	Moderate	Weak	Strong	Moderate
Other
Bar-Sela, 2019 [34]	Weak	Moderate	Weak	Strong	Weak	Weak
Gustavsen, 2021 [35]	Moderate	Moderate	Weak	Strong	Strong	Moderate
Withdrawal
Feinstein, 2019 [10]	Weak	Strong	Weak	Strong	Strong	Weak