Skip to main content
. Author manuscript; available in PMC: 2023 Jun 21.
Published in final edited form as: Annu Rev Biochem. 2022 Mar 23;91:89–106. doi: 10.1146/annurev-biochem-032620-105728

Figure 2.

Figure 2

Biophysical properties of purinosomes. (a) The size and number of PFAS–EGFP clusters in purine-depleted HeLa cells compared to other reported biomolecular condensates. (b) A representative lattice light-sheet fluorescence microscopy image of a purinosome-positive HeLa cell transfected with PFAS–mCherry. Analysis of these clusters showed that they are spherical, as demonstrated by the region of interest (yellow boxes). Panel b modified from the original image published in Pedley et al. (29) with permission from E.L. Kennedy and M. Kyoung. Abbreviations: EGFP, enhanced green fluorescent protein; P-body, processing body; PFAS, phosphoribosyl formylglycinamide synthase.