Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 3;24:65. doi: 10.1186/s13058-022-01562-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 2 — Transcriptomic and proteomic data indicated that KLF7 regulated ribosomal pathways. A GSEA of RNA-Seq data showing the top identified GO terms. B Overlap of identified genes and proteins in RNA-Seq and mass spectrometry. C GO term analysis of shot-gun proteomic data depicted the most regulated pathways. D Top significant GO-terms identified in transcriptomics and proteomics data overlapped. E Overlapping KEGG pathway of proteomics and transcriptomics data. Red: significantly altered proteins found in mass spectrometry; yellow: significantly modified genes identified in RNA-Seq; orange: compounds found in both screens. F Expression levels of ribosomal proteins in MS data in KLF7 compared to control. Red: 40S subunit; grey: 60S subunit. *p < 0.05. G Top regulated terms of the gene set enrichment analysis of The Cancer Genome Atlas (TCGA) data in patients stratified according to their KLF7 expression level