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. 2022 Sep 20;13:1003986. doi: 10.3389/fimmu.2022.1003986

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Copyright © 2022 Pernold, Lagumdzic, Stadler, Mair, Jäckel, Schmitt, Ladinig, Knecht, Dürlinger, Kreutzmann, Martin, Sawyer and Saalmüller

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Total number of NK cells and their differentiation over the study period of 126 weeks. Total NK cell numbers were calculated based on the percentages of CD3^-CD8α⁺CD16⁺ cells in total lymphocytes measured by FCM. (A) shows the gating strategy for a representative EGM (male, 18 weeks of age) for the determination of NK cells and the CD8α/NKp46-defined subsets. (B) Development of total NK cell numbers over time using CD3^-CD8α⁺CD16⁺ expression. Sexes are represented by black (male) and red colors (female). Phenotypic analyses of the NK-cell subsets by the expression of CD8α and NKp46 highlighted by different colors. CD8α^dim/+NKp46^high (black), CD8α⁺NKp46⁺ (blue), and CD8α⁺NKp46^- (red). Relative changes in the composition of the NK-cell subsets over time are presented for males (C) and females (D). + marks the first bleeding time point after transfer and vaccination, ++ marks the first bleeding time point after booster vaccinations.