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. 2022 Sep 20;13:1003986. doi: 10.3389/fimmu.2022.1003986

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Copyright © 2022 Pernold, Lagumdzic, Stadler, Mair, Jäckel, Schmitt, Ladinig, Knecht, Dürlinger, Kreutzmann, Martin, Sawyer and Saalmüller

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Gating strategy to distinguish CD8β⁺ T cells and CD27/perforin-defined subsets on the basis of a representative EGM (male, 18 weeks of age). (B) Total numbers of CD3⁺CD8β⁺ T cells were determined as described above over a study period of 126 weeks. Sexes are represented by black (male) and red colors (female). (C, D) Development of the relative composition of CD27/perforin-defined phenotypes over a study period of 126 weeks (C) males, (D) females. + marks the first bleeding time point after transfer and vaccination, ++ marks the first bleeding time point after booster vaccinations.