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. Author manuscript; available in PMC: 2022 Oct 4.
Published in final edited form as: Compr Physiol. 2022 Apr 26;12(3):3575–3620. doi: 10.1002/cphy.c210034

Figure 7. Sarcopenia.

Figure 7

Sarcopenia is the natural event that is characterized by muscle loss and function. At the muscle fiber level, it is observed as a reduction in the fiber quality, size, and number. There is also a reduction in the number and quality of satellite cells, which are stem cells that promote skeletal muscle homeostasis and repair. In the muscle cell, the sarcopenic process is not only driven by increased protein degradation and decreased synthesis, but also by oxidative stress, insulin resistance, ectopic fat accumulation, and inflammation. Multiple signaling pathways provide avenues for therapeutic intervention. Illustrations were obtained on https://smart.servier.com, Published by LES LABORATORIES SERVIER, SAS.