Table 1.
Baseline characteristics and risk factors for stroke in migraine with aura and stroke groups.
| Baseline | Stroke | Migraine with aura | p-value |
|---|---|---|---|
| Number of patients | 350 | 343 | |
| Age (median, IQR) | 71, 62–78 | 29, 28–52 | <0.001 |
| Number of women (n; %, f/m) | 39 | 69 | <0.001 |
| Days from index event or last aura attack to interview (median, IQR) | 2, 1–3 | 28, 7–118 | <0.001 |
| NIHSS, median, IQR (stroke only) | 1, 0–3 | ||
| Risk factors | |||
| Active smoking n (%) | 121 (34.6) | 103 (30) | 0.2 |
| Illicit drug use n (%) | 4 (1.1) | 14 (4.1) | 0.015 |
| High blood pressure n (%) | 233 (66.6) | 64 (18.7) | <0.001 |
| Dyslipidemia n (%) | 305 (87.4) | 29 (8.5) | <0.001 |
| Diabetes mellitus n (%) | 78 (22.3) | 8 (2.3) | <0.001 |
| Sleep apnea n (%) | 162 (46.3) | 14 (4.1) | <0.001 |
| Family history of stroke or myocardial infarction n (%) | 94 (26.9) | 76 (22.2) | 0.15 |
| Chronic kidney failure n (%) | 42 (12) | 1 (0.3) | <0.001 |
| Contraceptive hormonal treatment n (%) | 5 (3.6) | 36 (15.3) | <0.001 |
| Atrial fibrillation n (%) | 44 (12.6) | 3 (0.9) | <0.001 |
| Chronic inflammatory disease or active tumor n (%) | 47 (13.4) | 26 (7.6) | 0.012 |
| Co-morbidities | |||
| Migraine with aura (stroke only) n (%) | 15 (4) | ||
| History of ischemic stroke (migraine only) n (%) | 21 (6.1) | ||
| Epilepsy n (%) | 1 (0.3) | 7 (2) | 0.03 |
| Seizure at presentation (stroke only) n (%) | 2 (0.6) | ||
| Acute treatment (stroke only) | |||
| Conservative* n (%) | 221 (63.1) | ||
| IVT or IAT n (%) | 129 (36.9) | ||
| IAT only n (%) | 28 (8) | ||
| IVT only n (%) | 81 (23.1) | ||
| IVT and IVT n (%) | 20 (5.7) |
IQR, interquartile range; NIHSS, National Institutes of Health Stroke Scale; IAT, intra-arterial therapy; IVT, intravenous thrombolysis, *no IAT or IVT.