Table 1.
MC1R genotype and allele frequencies in Mexican Americans
| Order | SNP | Chromosome Position |
Allele | Phenotype | Depressed patient | Control | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Genotype (N = 181) | Genotype (N = 185) | |||||||||
| Major/Major | Major/Minor | Minor/Minor | Major/Major | Major/Minor | Minor/Minor | |||||
| 1 | New | 88513294 | G→A | G43R | 181 (100) | 0 (0) | 0 (0) | 184 (99.5) | 1 (0.5) | 0 (0) |
| 2 | rs1805005 | 88513345 | G→T | V60L | 163 (90.1) | 18 (9.9) | 0 (0) | 165 (89.2) | 19 (10.3) | 1 (0.5) |
| 3 | New | 88513416 | G→A | S83S | 181 (100) | 0 (0) | 0 (0) | 184 (99.5) | 1 (0.5) | 0 (0) |
| 4 | rs1805006 | 88513419 | C→A | D84E | 180 (99.4) | 1 (0.6) | 0 (0) | 184 (99.5) | 1 (0.5) | 0 (0) |
| 5 | rs2228479 | 88513441 | G→A | V92M | 167 (92.3) | 13 (7.2) | 1 (0.6) | 164 (88.6) | 20 (10.8) | 1 (0.5) |
| 6 | rs34158934 | 88513451 | C→T | T95M | 180 (99.4) | 1 (0.6) | 0 (0) | 185 (100) | 0 (0) | 0 (0) |
| 7 | New | 88513476 | C→T | A103A | 181 (100) | 0 (0) | 0 (0) | 184 (99.5) | 1 (0.5) | 0 (0) |
| 8 | rs3212364 | 88513485 | G→A | L106L | 180 (99.4) | 1 (0.6) | 0 (0) | 183 (98.9) | 2 (1.1) | 0 (0) |
| 9 | New | 88513500 | G→A | A111A | 177 (97.8) | 4 (2.2) | 0 (0) | 182 (98.4) | 3 (1.6) | 0 (0) |
| 10 | rs11547464 | 88513592 | G→A | R142H | 179 (98.9) | 2 (1.1) | 0 (0) | 183 (98.9) | 2 (1.1) | 0 (0) |
| 11 | rs1805007 | 88513618 | C→T | R151C | 181 (100) | 0 (0) | 0 (0) | 183 (98.9) | 2 (1.1) | 0 (0) |
| 12 | rs1110400 | 88513631 | T→C | I155T | 180 (99.4) | 1 (0.6) | 0 (0) | 182 (98.4) | 3 (1.6) | 0 (0) |
| 13 | rs1805008 | 88513645 | C→T | R160W | 181 (100) | 0 (0) | 0 (0) | 184 (99.5) | 1 (0.5) | 0 (0) |
| 14 | rs885479 * | 88513655 | G→A | R163Q | 79 (43.6) | 69 (38.1) | 33 (18.2) | 91 (49.2) | 74 (40) | 20 (10.8) |
| 15 | rs3212366 | 88513753 | T→C | F196L | 180 (99.4) | 1 (0.6) | 0 (0) | 185 (100) | 0 (0) | 0 (0) |
| 16 | New | 88513866 | G→A | Q233Q | 180 (99.4) | 1 (0.6) | 0 (0) | 184 (99.5) | 1 (0.5) | 0 (0) |
| 17 | New | 88513910 | G→A | Q248D | 181 (100) | 0 (0) | 0 (0) | 184 (99.5) | 1 (0.5) | 0 (0) |
| 18 | New | 88513970 | C→G | P268R | 181 (100) | 0 (0) | 0 (0) | 184 (99.5) | 1 (0.5) | 0 (0) |
| 19 | New | 88513987 | G→A | G274S | 181 (100) | 0 (0) | 0 (0) | 184 (99.5) | 1 (0.5) | 0 (0) |
| 20 | rs1805009 | 88514047 | G→C | R294P | 177 (97.8) | 3 (1.7) | 1 (0.6) | 183 (98.9) | 2 (1.1) | 0 (0) |
| 21 | rs3212367 | 88514067 | C→T | F300F | 181 (100) | 0 (0) | 0 (0) | 184 (99.5) | 1 (0.5) | 0 (0) |
| 22 | rs2228478 | 88514109 | A→G | T314T | 155 (85.6) | 25 (13.8) | 1 (0.6) | 146 (78.9) | 35 (18.9) | 4 (2.2) |
| 23 | rs3212368 | 88514133 | G→A | 3'UTR | 177 (97.8) | 4 (2.2) | 0 (0) | 180 (97.3) | 5 (2.7) | 0 (0) |
*
This SNP is significantly associated with depression (P = 0.04).