Fig 4. PKM2 deletion in mSC impairs motor performance recovery after DCA treatment.

A- Metabolic pathways directly affected by the manipulations. LDH: lactate dehydrogenase; PDH: pyruvate dehydrogenase; PDK: PDH kinase. B- Rotarod latency to fall was measured in 9 months old Control (n = 5) and Mutant mice (n = 5) during a 7 weeks daily treatment with DCA and then during a three weeks recovery period without treatment. Two-way non repeated measures ANOVA Sidak’s post-hoc test from week 7 to week 10. C- Nerve conduction velocity (NCV) measured in 9 months old Control (n = 5) and Mutant mice (n = 7) at 0, 3 and 7 weeks of DCA treatment and 3 weeks after stopping the treatment (week 10). Two-way non repeated measures ANOVA statistical tests, Sidak’s post-hoc tests over the 4 time points. Error bars represent SEM.