Table 2.
Factors affecting the overall response rate: univariate and multivariate analyses.
| Univariate | Multivariate | |||||||
|---|---|---|---|---|---|---|---|---|
| Variable | ORR% | RR | C.I. 95% | P value | RR | C.I. 95% | P value | |
| Age | <80 yrs >80 yrs |
78% 80% |
0.91 | 0.54-1.57 | 0.7519 | |||
| Stage | T1-T2 T3-T4 |
82% 70% |
1.95 | 1.02-3.72 | 0.0425 | 1.02 | 0.47-2.19 | 0.9597 |
| # Previous tr | 0 1 2 >2 |
86% 82% 76% 57% |
1.52° | 1.16-1.99 | 0.0057 | 1.52 | 1.09-2.12 | 0.0129 |
| ECOG | 0-1+
2-3-4 |
81% 69% |
1.87 | 0.99-3.52 | 0.0529 | |||
| Presentation | Primary Locally advanced |
85% 75% |
1.88 | 1.09-3.23 | 0.0226 | 1.61 | 0.87-3.00 | 0.1319 |
| Site | Head/neck/scalp Trunk Limbs |
78% 84% 83% |
1.17* 1.10* |
0.59-2.29 0.66-1.81 |
0.6455 0.7195 |
|||
| Current delivered | 0-3 Å 3-7 Å >7 Å |
80% 81% 79% |
1.08° | 0.87-1.36 | 0.4859 | |||
| Drug administration | Intravenous Intratumoural |
85% 53% |
5.00 | 2.73-9.15 | 0.0001 | 4.83 | 2.41-9.67 | 0.0001 |
| Preirradiated | No Yes |
82% 70% |
1.95 | 1.04-3.66 | 0.0319 | 1.06 | 0.49-2.29 | 0.8885 |
| Lymphoedema | No Yes |
79% 96% |
0.15 | 0.02-1.09 | 0.0681 | |||
| Size | <30 mm ≥30 mm |
83% 71% |
1.96 | 1.14-3.39 | 0.0154 | 2.28 | 1.20-4.33 | 0.0114 |
| Electrode | Hexagonal Other |
82% 76% |
1.44 | 0.85-2.45 | 0.1762 | |||
+ 0, fully active; 1, restricted in physically strenuous activity; 2, ambulatory and capable of all self-care; 3, capable of only limited self-care; 4, completely disabled. *RR versus site head/neck/scalp. °RR on ordinal variables. RR, relative risk; C.I. 95%, confidence interval at 95%.