Table 4.
Multivariable analyses assessing outcomes after pre-injury coagulant use in geriatric patients with traumatic intracranial hemorrhage after a fall
| Variable | Outcome model | ||||
|---|---|---|---|---|---|
| Specific reversal agent | Neurosurgical intervention | In-hospital mortality or hospice | Day 3 mortality or hospice | Inpatient rehabilitation | |
| Pre-injury anticoagulant | – | – | – | – | |
| DOAC | 0.28 (0.15–0.54) | 3.14 (1.36–7.28) | 1.06 (0.42–2.68) | 0.58 (0.76–4.40) | 0.62 (0.31–1.25) |
| VKA | 1.00 (Reference) | 1.41 (0.94–2.10) | 1.62 (1.15–2.27) | 1.43 (0.89–2.31) | 1.41 (1.06–1.87) |
| None | – | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| Male sex | 1.00 (0.67–1.50) | 0.78 (0.54–1.13) | 0.92 (0.68–1.26) | 1.21 (0.79–1.87) | 1.17 (0.91–1.49) |
| CCI (per point) | 0.99 (0.85–1.15) | 0.80 (0.69–0.93) | 1.34 (1.20–1.49) | 1.24 (1.07–1.44) | 1.02 (0.93–1.12) |
| TBI severity (Glasgow coma scale) | – | – | – | – | |
| Mild (13–15) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| Moderate (9–12) | 1.40 (0.59–3.34) | 1.49 (0.78–2.87) | 3.33 (2.04–5.44) | 3.17 (1.59–6.34) | 1.43 (0.83–2.44) |
| Severe (3–8) | 0.93 (0.47–1.82) | 1.28 (0.80–2.05) | 9.72 (6.48–14.57) | 12.81 (7.91–20.75) | 1.59 (0.92–2.75) |
| AIS-head (per point) | 1.11 (0.86–1.44) | 5.57 (3.93–7.89) | 2.60 (2.04–3.31) | 3.16 (2.16–4.63) | 1.60 (1.36–1.89) |
| Other Tbi | 0.94 (0.59–1.51) | 0.63 (0.40–0.99) | 1.87 (1.33–2.63) | 1.52 (0.95–2.43) | 1.17 (0.88–1.56) |
| Skull fracture | 0.78 (0.34–1.76) | 1.20 (0.69–2.08) | 1.19 (0.77–1.85) | 1.65 (0.95–2.88) | 0.93 (0.63–1.37) |
DOAC direct oral anticoagulant, VKA vitamin K antagonist, CCI Charlson comorbidity index, TBI traumatic brain injury, ISS injury severity score
Results are post-collinearity correction and are presented as odd ratio (95% Confidence interval)