Table 3.

Associations of ACE scores (Total, Maltreatment, Household Dysfunction) with Biological Aging.

	AgeAccelPheno			AgeAccelGrim
	b (95% CI)	β	p-value	b (95% CI)	β	p-value
Total ACE score
Model 1	0.230 [−0.336, 0.797]	0.091	0.421	0.015 [−0.088, 0.117]	0.032	0.778
Model 2	0.165 [−0.520, 0.850]	0.065	0.632	−0.020 [−0.122, 0.082]	−0.044	0.697
Maltreatment
Model 1	1.16 [0.353, 1.96]	0.307	0.005	.0005 [−0.147, 0.157]	0.008	0.944
Model 2	1.05 [0.123, 1.97]	0.277	0.027	−0.04 [−0.185, 0.099]	−0.063	0.552
Model 3a	1.21 [0.309, 2.12]	0.322	0.009	−0.044 [−0.190, 0.101]	−0.065	0.544
Household Dysfunction
Model 1	−0.820 [−1.75, 0.111]	−0.194	0.083	0.034 [−0.137, 0.204]	0.044	0.697
Model 2	−1.06 [−2.18, 0.071]	−0.249	0.066	0.005 [−0.167, 0.178]	0.007	0.95
Model 3b	−1.29 [−2.38, −0.194]	−0.304	0.022	0.014 [−0.161, 0.189]	0.018	0.875

Note the opposite direction of association between epigenetic age acceleration and maltreatment or household dysfunction score.

Model 1. Unadjusted model.

Model 2. Adjusted for gender, BMI, smoking status, race, household income and DNAm-based markers of immune cell composition.

^aModel 3. Model 2 further adjusted for Household Dysfunction score.

^bModel 3. Model 2 further adjusted for Maltreatment score.