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. 2022 Oct 4;12:16566. doi: 10.1038/s41598-022-20975-1

Figure 7.

Figure 7

(A, B) A classifier trained on 5hmC levels in enhancer regions maintains performance at early-stage cancer(CRC Stage vs AUC: Spearman’s rho = 0.80, p = 0.333) compared to a model trained on cfDNA fragment size and coverage (DELFI-like approach) (CRC Stage vs AUC: Spearman’s rho = 0.95, p = 0.05). (C) The 5hmC-based classifier performs comparably to reported classifiers for stage 1 CRC. To gain approximately comparable confidence intervals, 95% binomial confidence intervals were computed for all classifiers using publicly available information8,12,33,34,38. The CRC classifier from Putcha et al. contains both Stage 1 and Stage 2 samples.