Table 3.
Training performance of 5hmC classifiers for other cancers and conditions.
| Condition | AUC (%) | Sensitivity at 90% | Sensitivity at 95% |
|---|---|---|---|
| CRC vs controls | 90 (87–93) | 71 (60–81) | 55 (36–71) |
|
CRC vs controls (weighted for additional clinical covariates) |
90 (87–93) | 72 (59–81) | 59 (38–72) |
| CRC vs controls and adenomas | 83 (80–86) | 61 (46–73) | 31 (23–44) |
| Lung cancer vs controls | 80 (73–87) | 37 (21–73) | 18 (11–38) |
| Breast cancer vs controls | 82 (75–89) | 33 (22–56) | 16 (11–29) |
| Prostate cancer vs controls | 79 (71–88) | 30 (20–54) | 15 (10–28) |
| CRC vs other cancers | 78 (74–82) | 34 (26–47) | 17 (13–24) |