Table 5.
The 5hmC classifier trained for CRC vs controls was applied to the validation data set. 95% CI computed using Binomial Proportions Test.
| Disease | Stage | % CRC | 95% CI | CRC | N |
|---|---|---|---|---|---|
| Advanced adenoma | 21.95 | (13.0, 31.0) | 18 | 82 | |
| Arthritis | 0.00 | (0.0, 0.0) | 0 | 7 | |
| Breast cancer | 1 | 33.33 | (0.0, 87.0) | 1 | 3 |
| Breast cancer | 2 | 31.58 | (11.0, 52.0) | 6 | 19 |
| Breast cancer | 3 | 25.00 | (0.0, 55.00) | 2 | 8 |
| Breast cancer | 4 | 75.00 | (33.0, 100.0) | 3 | 4 |
| COPD | 50.00 | (0.0, 100.0) | 1 | 2 | |
| Colorectal cancer | 1 | 77.78 | (66.0, 90.0) | 35 | 45 |
| Colorectal cancer | 2 | 85.06 | (78.0, 93.0) | 74 | 87 |
| Colorectal cancer | 3 | 75.41 | (65.0, 86.0) | 46 | 61 |
| Colorectal cancer | 4 | 92.59 | (83.0, 100.0) | 25 | 27 |
| Control | 17.45 | (11.0, 24.0) | 26 | 149 | |
| Lung cancer | 1 | 42.86 | (17.0, 69.0) | 6 | 14 |
| Lung cancer | 2 | 68.75 | (46.0, 91.0) | 11 | 16 |
| Lung cancer | 3 | 71.43 | (48.0, 95.0) | 10 | 14 |
| Lung cancer | 4 | 85.71 | (60.0, 100.0) | 6 | 7 |
| Non-advanced adenoma | 15.91 | (8.0, 24.0) | 14 | 88 | |
| Ovarian cancer | 1 | 83.33 | (54.0, 100.0) | 5 | 6 |
| Ovarian cancer | 3 | 100.00 | (100.0, 100.0) | 4 | 4 |
| Prostate cancer | 1 | 100.00 | (100.0, 100.0) | 1 | 1 |
| Prostate cancer | 2 | 54.55 | (25.0, 84.0) | 6 | 11 |
| Prostate cancer | 3 | 12.50 | (0.0, 35.0) | 1 | 8 |
| Prostate cancer | 4 | 80.00 | (45.0, 100.0) | 4 | 5 |
| Stomach cancer | 1 | 100.00 | (100.0, 100.0) | 1 | 1 |
| Stomach cancer | 2 | 100.00 | (100.0, 100.0) | 5 | 5 |
| Stomach cancer | 3 | 100.00 | (100.0, 100.0) | 2 | 2 |
| Ulcers | 16.67 | (0.0, 46.0) | 1 | 6 | |
| Bladder cancer | 1 | 100.00 | (100.0, 100.0) | 5 | 5 |
| Bladder cancer | 2 | 100.00 | (100.0, 100.0) | 1 | 1 |
| Bladder cancer | 3 | 100.00 | (100.0, 100.0) | 1 | 1 |
| Bladder cancer | 4 | 100.00 | (100.0, 100.0) | 2 | 2 |