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. 2022 Oct 5;7:346. doi: 10.1038/s41392-022-01150-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — ITH of SCLC is recapitulated in relapsed tumors. a UMAP plot of malignant cells from SCLC-P2 revealed three specific clusters (indicated by color). b UMAP plot of malignant cells from SCLC-P2 revealed specific clusters in the primary and relapsed tumors by the cell of origin. c Heatmap shows the DEGs and related pathways that correspond to the primary and relapsed tumors, as well as the three specific clusters. d GSEA of all DEGs using hallmark gene set collections. The top 3 enriched hallmarks (ranked by the FDR q-values) along with the number of mapped and total genes in the pathways are shown