Table 1.
Urinalysis results of male and female rats treated with HU033 in the 13-week repeated oral dose toxicity study
| Dose (mg/kg/day) | Male | Female | ||||||
|---|---|---|---|---|---|---|---|---|
| 0 | 500 | 1000 | 2000 | 0 | 500 | 1000 | 2000 | |
| No. of animals | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| Volume (mL) | ||||||||
| Mean | 9.7 | 11.5 | 13.9 | 11.7 | 5.3 | 5.8 | 5.4 | 5.5 |
| SD | 1.4 | 2.9 | 4.9 | 3 | 1.6 | 2.1 | 1 | 2.2 |
| Color | ||||||||
| Pale yellow | 3 | 1 | 1 | |||||
| Yellow | 5 | 2 | 4 | 5 | 4 | 5 | 5 | 5 |
| Transparency | ||||||||
| Clear | 5 | 5 | 5 | 5 | 5 | 5 | 4 | 4 |
| Mild turbidity | 1 | 1 | ||||||
| pH | ||||||||
| 6 | ||||||||
| 6.5 | 1 | |||||||
| 7 | 1 | |||||||
| 8 | 4 | 5 | 4 | 4 | 4 | 3 | 2 | 1 |
| 9 | 1 | 1 | 2 | 3 | 4 | |||
| Protein (mg/dL) | ||||||||
| – | 1 | 3 | 1 | 5 | 5 | 4 | 5 | |
| 25 | 4 | 2 | 4 | 5 | 1 | |||
| Glucose | ||||||||
| Normal | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| Ketone body | ||||||||
| – | 1 | 5 | 3 | 4 | 2 | 1 | ||
| 5 | 3 | 2 | 4 | 1 | 3 | 3 | 5 | |
| 15 | 1 | 1 | 1 | |||||
| 150 | ||||||||
| Bilirubin (mg/dL) | ||||||||
| – | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| Occult blood (Ery/μL) | ||||||||
| – | 5 | 5 | 4 | 5 | 5 | 5 | 5 | 5 |
| 50 | 1 | |||||||
| Casta | ||||||||
| 0 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| Epithelial cella | ||||||||
| 0 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| Leukocytea | ||||||||
| 0 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| Erythrocytea | ||||||||
| 0 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| Specific gravity | ||||||||
| 1.021–1.030 | 1 | 1 | 1 | |||||
| 1.031–1.040 | 1 | 2 | 1 | |||||
| 1.041–1.050 | 1 | 2 | 2 | 2 | 3 | 1 | 1 | 2 |
| 1.051–1.060 | 2 | 3 | 1 | 3 | 2 | 3 | 1 | |
| > 1.060 | 2 | 2 | ||||||
SD standard deviation
aSediment