Table 2.

Relative organ weights of male and female rats treated with HU033 in the 13-week repeated oral dose toxicity study (results are presented as the mean ± SD, n = 10)

	Dose (mg/kg/day)
	0	500	1000	2000
No. of rats	10	10	10	10
Male
Brain	0.39 ± 0.03	0.38 ± 0.03	0.41 ± 0.03	0.38 ± 0.03
Pituitary	0.0022 ± 0.0002	0.0024 ± 0.0003	0.0024 ± 0.0002	0.0022 ± 0.0002
Thyroid	0.0058 ± 0.0007	0.0057 ± 0.0009	0.0061 ± 0.0008	0.0058 ± 0.0008
Thymus	0.06 ± 0.02	0.06 ± 0.02	0.06 ± 0.01	0.07 ± 0.02
Heart	0.29 ± 0.02	0.31 ± 0.02	0.31 ± 0.03	0.30 ± 0.03
Lung	0.32 ± 0.02	0.31 ± 0.02	0.32 ± 0.02	0.30 ± 0.02
Liver	2.68 ± 0.14	2.67 ± 0.24	2.76 ± 0.19	2.76 ± 0.17
Spleen	0.17 ± 0.02	0.16 ± 0.01	0.16 ± 0.03	0.16 ± 0.02
Kidney	0.60 ± 0.04	0.60 ± 0.05	0.64 ± 0.05	0.65 ± 0.04
Adrenal	0.0125 ± 0.0022	0.0125 ± 0.0019	0.0120 ± 0.0020	0.0120 ± 0.0033
Testis	0.66 ± 0.07	0.60 ± 0.16	0.71 ± 0.08	0.66 ± 0.10
Epididymis	0.28 ± 0.02	0.26 ± 0.06	0.30 ± 0.04	0.27 ± 0.03
Prostate	0.11 ± 0.02	0.12 ± 0.03	0.11 ± 0.02	0.12 ± 0.03
Female
Brain	0.70 ± 0.08	0.63 ± 0.06	0.68 ± 0.05	0.65 ± 0.06
Pituitary	0.0059 ± 0.0009	0.0052 ± 0.0009	0.0058 ± 0.0011	0.0052 ± 0.0007
Thyroid	0.0074 ± 0.0013	0.0077 ± 0.0011	0.0079 ± 0.0015	0.0076 ± 0.0014
Thymus	0.09 ± 0.02	0.09 ± 0.01	0.09 ± 0.02	0.10 ± 0.02
Heart	0.34 ± 0.04	0.33 ± 0.03	0.34 ± 0.02	0.32 ± 0.02
Lung	0.42 ± 0.02	0.40 ± 0.04	0.40 ± 0.02	0.40 ± 0.02
Liver	2.44 ± 0.20	2.43 ± 0.11	2.47 ± 0.22	2.43 ± 0.12
Spleen	0.18 ± 0.01	0.17 ± 0.01	0.17 ± 0.02	0.17 ± 0.02
Kidney	0.63 ± 0.05	0.64 ± 0.05	0.66 ± 0.05	0.64 ± 0.04
Adrenal	0.0248 ± 0.0022	0.0224 ± 0.0037	0.0249 ± 0.0049	0.0231 ± 0.0030
Ovary	0.309 ± 0.0081	0.0278 ± 0.0046	0.0278 ± 0.0058	0.0281 ± 0.0052
Uterus	0.21 ± 0.05	0.21 ± 0.06	0.22 ± 0.06	0.25 ± 0.06